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PMCID: PMC6819021

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Accordingly, Nasca and coworkers found that chronic unpredictable stress causes large reductions in hippocampal mGlu2 receptors exclusively in mice that are not resilient to stress, and that mice lacking mGlu2 receptors are more susceptible to stress [138]

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However, the estimates variability and degree of uncertainty are indicated by the broad confidence intervals, especially in the random effects model ( Figure 9 )